Influence of Thermoelectric Coupling on Pacemaker Activity Generated by Mechano-electric Feedback in a One-dimensional Ring-shaped Model of Cardiac Fiber
نویسندگان
چکیده
Recently, the influence of thermal processes on electrophysiology has clearly been underlined by Bini et al. [2], using a FitzHugh–Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases [2]. In the present study, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on pacemaker activity generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional ring-shaped electromechanical model of cardiac fiber, which takes into account excitation-contraction coupling (ECC), as well as MEF.
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